Factor X Variant Database

Terms with a '*' next to them are explained on the Help Page .

Undefined cDNA (R182M)

p.Arg182Met (Legacy AA No. 142)

Variant Type:

Point

Domain:

Linker

Location:

Exon 6

Variant Effect:

Missense

Codon Change:

No. of Patients Reported:

Phenotype:

Allele Count *:

Allele Number *:

Allele Frequency *:

Residue Information:

	Name	Type	Cyclic	Size	Position	Hydrophobicity	Charge
Wild Type	Arg	basic	acyclic	large	surface	hydrophilic	postive
Mutated	Met	-	acyclic	large	buried	hydrophobic	neutral

Grantham Score : 91

PolyPhen-2 Prediction : Probably Damaging (SCORE: 0.999)

SIFT Prediction : Tolerated (SCORE: 0.08)

PROVEAN Prediction : Deleterious (SCORE: -2.869)

Arg182 is in a region on the surface of the FX structure that is undefined. Hence the FX structure and its JMOL applet are not shown below.

NOTE: If no Java applet appears or a Java error message is shown, please click the following LINK.

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Factor X Variant Database