Factor X Variant Database

Terms with a '*' next to them are explained on the Help Page .

c.574G>C

p.Gly192Arg (Legacy AA No. 152)

Variant Type:

Point

Domain:

Activation peptide

Location:

Exon 6

Variant Effect:

Missense

Codon Change:

G>C

No. of Patients Reported:

Phenotype:

Allele Count *:

Allele Number *:

248970

Allele Frequency *:

0.000004

Residue Information:

	Name	Type	Cyclic	Size	Position	Hydrophobicity	Charge
Wild Type	Gly	aliphatic	acyclic	small	surface	hydrophobic	neutral
Mutated	Arg	basic	acyclic	large	surface	hydrophilic	postive

Grantham Score : 125

PolyPhen-2 Prediction : Possibly Damaging (SCORE: 0.682)

SIFT Prediction : Tolerated (SCORE: 0.14)

PROVEAN Prediction : Neutral (SCORE: 0.116)

Gly192 is in a region on the surface of the FX structure that is undefined. Hence the FX structure and its JMOL applet are not shown below.

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Factor X Variant Database